Um, yeah, you can, I've done it a few thousand times now.but the wolves have a quick leg sweep you can't seem to block.
Really the best way to kill him depends on what you're good at. If you're only good at stealth kills then you're pretty much assured death, because wolves always hear or smell you coming.
If you're good at blocks and reversals, if you can, grab a knife and just reverse his attacks, the knife gives you extra damage to the wolf.
If you're good at stright forward melee "Punch U Punch Me" fights then just have at him.
A good way to kill a wolf however that doesn't require much skill is have a spare body around and lure him over to it. When he's pretty close do the move where you pick up the body and punch it away (In case you don't know how to do this is crouch over the body and hit attack. Make sure you're facing the enemy though)